Angiotentsinaren entzima bihurtzaile

ACE
Proteinak kodetzen dituen genea
Identifikadoreak
Homologene: 37351 Genenames: ACE Ensemble: ENSG00000159640
Taxoia	Homo sapiens
Asoziazio-genetikoa	diabetic nephropathy (en) hipertentsio
Kokapena
Kromosoma	human chromosome 17 (en)
Kokapen zitogenetikoa	17q23.3
Hasiera	63477061 bp[1]
Amaiera	63498380 bp[2]
Transkripzioak
RNA ID	XM_006721737, NM_000789, NM_001178057, NM_152830, NM_152831, NM_001382700, NM_001382701, NM_001382702 eta NR_168483
Ensembl	Zerrenda ENST00000584865 ENST00000290863 ENST00000290866 ENST00000413513 ENST00000428043 ENST00000577418 ENST00000578679 ENST00000578839 ENST00000579204 ENST00000579314 ENST00000579462 ENST00000579726 ENST00000580318 ENST00000582005 ENST00000582244 ENST00000582627 ENST00000582678 ENST00000582761 ENST00000583336 ENST00000583645 ENST00000584529
Sagu arrunt	Ace (en)
Arratoi arrunt	Ace (en)
Danio rerio	ace (en)
Ontologia
Kodetzen du	angiotentsinaren entzima bihurtzaile
Funtzio-molekularrak	Ikusi tripeptidyl-peptidase activity (en) zinc ion binding (en) exopeptidase activity (en) endopeptidase activity (en) metal ion binding (en) mitogen-activated protein kinase binding (en) bradykinin receptor binding (en) peptidase activity (en) proteina lotura carboxypeptidase activity (en) chloride ion binding (en) actin binding (en) mitogen-activated protein kinase kinase binding (en) hydrolase activity (en) metallodipeptidase activity (en) metallopeptidase activity (en) peptidyl-dipeptidase activity (en) metallopeptidase activity (en) exopeptidase activity (en) dipeptidyl-peptidase activity (en) peptidyl-dipeptidase activity (en)
Osagai-zelularra	Ikusi zitoplasma zelula-mintzaren osagai integrala endosoma mintza Lisosoma extracellular exosome (en) external side of plasma membrane (en) zelulaz kanpoko eremu zelula mintz extracellular space (en) extracellular space (en) zelula mintz extracellular exosome (en)
Prozesu-biologikoak	Ikusi regulation of renal output by angiotensin (en) antigen processing and presentation of peptide antigen via MHC class I (en) amyloid-beta metabolic process (en) angiotensin maturation (en) blood vessel remodeling (en) regulation of vasoconstriction (en) hematopoietic stem cell differentiation (en) regulation of angiotensin metabolic process (en) regulation of smooth muscle cell migration (en) mononuclear cell proliferation (en) regulation of systemic arterial blood pressure by renin-angiotensin (en) arachidonic acid secretion (en) peptide catabolic process (en) blood vessel diameter maintenance (en) proteolisi kidney development (en) neutrophil mediated immunity (en) positive regulation of systemic arterial blood pressure (en) Espermatogenesi regulation of blood pressure (en) posttranscriptional regulation of gene expression (en) negative regulation of gene expression (en) negative regulation of protein binding (en) positive regulation of protein binding (en) hormone catabolic process (en) heart contraction (en) positive regulation of protein tyrosine kinase activity (en) cell proliferation in bone marrow (en) positive regulation of peptidyl-tyrosine autophosphorylation (en) regulation of hematopoietic stem cell proliferation (en) negative regulation of gap junction assembly (en) positive regulation of peptidyl-cysteine S-nitrosylation (en) angiotensin maturation (en) regulation of systemic arterial blood pressure by renin-angiotensin (en) positive regulation of systemic arterial blood pressure (en) positive regulation of blood pressure (en)

Angiotentsinaren entzima bihurtzailea (AEB edo ACE) I angiotentsina izeneko substantzia II angiotentsina (giza gorputzeko hodi-uzkurtzailerik indartsuena) bihurtzen duen entzima da. Bradikinina hipotentsorearen inaktibazioa estimulatzen duen II kininasaren berdina da entzima hori, eta, beraz, AEBak funtsezko eginkizuna du presio arterialaren erregulazioan.^[3]. Hainbat gorputz-ehunek sortzen dute, hala nola nerbio-sistema zentralak, giltzurrunak eta birikak.

1. ↑ GRCh38: Ensembl release 89: ENSG00000159640. Ensembl.
2. ↑ GRCh38: Ensembl release 89: ENSG00000159640. Ensembl.
3. ↑ Euskalterm: [Kardiologia Hiztegia] [2023]